- Gizmodo (Jan 27, 2021) - "Doctors Studied People's Last Moments of Life to Figure Out When Death Begins"
- The Toronto Star (Jan 27, 2021) - "When can a person be declared dead after life-saving measures stop? A major new study has an answer"
- The Conversation (Jan 28, 2021) - "When is Dead, Really Dead? What happens after a person 'flatlines'?"
- The Guardian (Jan 28, 2021) - "How dead is dead? The heart can stop and re-start several times as a person dies, new study finds"
- The Ottawa Citizen (Jan 28, 2021) - "CHEO-led study examines dying process to inform organ donation"
- VICE News (Jan 29, 2021) - "Scientists Monitored 631 People As They Died. This Is What They Found"
- CBC News (Jan 31, 2021) - "When are you really dead? Study aims to dispel myths, remove barriers to organ donation"
- University of Alberta: Folio (Feb 2, 2021) - "'Five-minute-rule' holds true for cardiac death of organ donors: study"
The main results of the DePPaRT study have now been officially published as of January 28th in the New England Journal of Medicine. Check out the original publication by clicking on the link below.
Publication of this long-awaited paper has been met with several interviews and media reports, including:
After more than 5 years of hard work, we are thrilled to announce that the DePPaRT study is now complete! Our core team (with invaluable help from site coordinators and waveform adjudicators) has worked hard to review and finalize data, and we have completed the main study analysis. Along the way we have continued to publish papers, engage new colleagues, and build collaborations all over the world.
Although the DePPaRT data collection and main study analysis have been finalized, there remains much to do. Some ongoing exciting projects include:
In addition to this scientific work, our team is actively engaging with stakeholders and policy-makers as part of a knowledge translation strategy to ensure that our results are appropriately disseminated. A notable part of this initiative includes integration with Canadian Blood Services' initiative to harmonize criteria for death determination. Check back soon for updates and links to other knowledge translation activities!
As we move into the busy fall season, we thought this would be a good opportunity to give you another quick update on the progress of the DePPaRT study and our larger research program. Here are the recent highlights:
Given all the exciting developments for current and future work, we plan to organize a meeting of our Steering Committee in late October or early November. As we finish data analysis and begin the process of publishing and presenting DePPaRT results, and begin to embark on all the new research projects borne from DePPaRT, we want to reaffirm our sincere appreciation and gratitude for all our co-investigators, collaborators, coordinators, and partners in your continued support and dedication to this work.
We said goodbye to 2017 on a good note (Canadian recruitment finished!) and are looking forward to 2018 as we begin analysis and presentation of our results. The study team is sending out best wishes for 2018 and a huge thank you to all of the participating families and research sites that continue to make this study possible. We could not have done it without you!
Recent Study Updates:
A recent study update report is available on the updates page. Check back for updates about upcoming presentations and publications of study results.
Last week, clinicians, researchers, patients, and family members from Canada and Europe gathered in Mont Tremblant for the first DePPaRT International Planning Meeting to discuss some preliminary results from the DePPaRT data as well as to set goals for the next steps of this exciting research. It was so exciting and energizing to finally get the chance to have a face to face meeting with collaborators that we've been working with electronically for years. Thank you to everyone who came out and contributed to thinking about how to use the data we have, how to move forward with new ideas, and especially a big thanks to our patient and family partners for helping to remind us of why we continue to do this important research!
As we move into the busy fall season, we thought this would be a good opportunity to provide a quick update on the progress of the DePPaRT study. Enrolment continues to move along as anticipated, and our plan is to close study enrolment on December 1, 2017 for the majority of our Canadian sites, with only a few late joining and international sites continuing to enrol into 2018. Here's a quick list of updates:
Spring brings more of the same for the DePPaRT team, which is great news for us! Study enrolment continues to move along well in Canada and internationally, and if the current rates of recruitment continue we plan on closing the majority of sites to enrolment by the end of the year. Additional updates:
The DePPaRT study remains on track and we are happy to be concluding 2016 with a whole list of achievements:
In other news, we are very pleased to welcome Mélanie Hogue, former NICU nurse, to our core team to help with coordinating the study.
On behalf of the core team, we are wishing all our coordinators, collaborators, investigators, and patient families a safe and happy holidays.
The DePPaRT study is now just 15 patient enrolments away from our 250 patient halfway point!! Total enrolment is now at 235 patients.
Other updates this month include:
A more detailed breakdown of our enrolment numbers is available on our study progress page.
As an add-on to the DePPaRT study, researchers at the London Health Sciences Centre in London, Ontario have provided families the option to consent not just to existing clinical monitoring, but also to add an EEG machine to monitor what happens to the brain during the process of withdrawal of life sustaining therapies and after death. So far, several patient families have consented, and the local team has been able to collect continuous EEG, blood pressure with arterial wave forms, EKG activity and oxygen saturations.
Recently, the London team presented an abstract of their progress to date at the Canadian Neurological Sciences Congress in Quebec City (read the abstract here). Researcher Loretta Norton says the poster generated a lot of interest amongst neurologists at the congress, and she is looking forward to getting additional feedback from a broader audience, including from any interested DePPaRT investigators.
Congratulations Loretta and the London team on a great poster presentation and for leading this important neurological aspect of DePPaRT!
Amanda van Beinum