Thank you to our hard working site coordinators & Czech collaborators for enrolling more than 20 patients since the last update –total study enrolment is now at 144 patients! If we maintain this rate of enrolment we project to complete enrolment by the end of summer 2017.
Special thanks to coordinators at the Ottawa Civic and Hamilton sites for enrolling two new DCD patients this month. The DCD enrolments always seem to be a little bit more demanding than the non-donor patients due to the need for extra attention to detail and coordination with the transplant teams so thank you for everyone who has made the effort to make this work. These patients provide very valuable information for us. So far 8 DCD patients have been enrolled in the study.
Additional details on DePPaRT study enrolment are available on the study progress page.
It may be freezing weather but the DePPaRT study is anything but frozen!
In January and February of 2016 the dedication of our site coordinators and our collaborators in Prague have led us to meet for the first time our target enrolment rate of about 20 patients per month. Total study enrolment is now at 122 patients after almost 1 year since the first adult sites in Ottawa and Prague opened.
The Všeobecná fakultní nemocnice v Praze (General University Hospital in Prague) joined us as a site in February, and site investigator Dr. Kateřina Rusinová has already enrolled her first patient!
We look forward to opening another site in Liberec, Czech Republic soon, as well as one site in Halifax, Nova Scotia.
Check out the February update on our progress page for more details about study enrolment.
In January 2016 the 100th patient was enrolled in DePPaRT (Can you believe our 50th patient was just enrolled in November??), amidst a flurry of other exciting updates:
January updates on study screening and enrolment are now available on our updates page.
The central DePPaRT coordinating team met last week to discuss the incredible progress we've made this year, and to make new plans for 2016. We are so grateful to all of our site coordinators, investigators, and of course the families and friends of the patients enrolled who have made this study possible. As of this morning, a total of 70 patients have now been enrolled in the study, making this the largest prospective cohort of continuously physiologically monitored patients after withdrawal of life sustaining therapy ever! (At least, to our knowledge). Our group is looking forward to continued collaboration with all our site teams and possibly some new projects on the way for next year...
On behalf of the DDePICt group (Sonny, Sam, Laura, Amanda, and Nathan), wishing you and your families a safe and happy holidays!
From left to right: David Hartell from CNTRP, Nathan Scales, Sonny Dhanani, Amanda van Beinum, and Laura Hornby from the DePPaRT research group.
December study updates now available on our updates page.
We were pleased to reach and surpass our major milestone of 50 patients this month - enrolment is now at 58 patients!
Despite this success, enrolment has been slower this month due to some unforeseen challenges at several of our Canadian sites, including staffing issues and technical problems with waveform collection.
We plan to address these challenges before the New Year and we are planning a conference call for all site investigators for early in the New Year to discuss study progress and next steps.
For more detailed information on study progress, check out the latest update report on our study progress page.
This week, Sonny is the focus of CHEO's Spotlight on Research. Click on the video below to watch him explain how our work uncovering the barriers to organ donation is impacting the lives of pediatric donors and their families.
We are pleased to announce that the DePPaRT study has, as of this week, enrolled the 50th patient! Our total count is now at 51 patients - that's 51 deaths in ICU where families made the generous decision to allow us to use the patient's data to improve our knowledge of the physiology of dying, and help to influence organ donation policy.
Thank you to all our consenting families, hard working and cooperative bedside staff, and of course our site study teams who are making this study happen through consistent screening, consenting, and data collection!!
The DePPaRT study has come a long way in the past few months. At 48 patients total, we have now surpassed the number enrolled in the DDePICt pilot study and are only 2 patients away from our next major milestone.
A big thanks to our stellar team in Prague who have now enrolled almost half of all our patients (21 in total, as of today), and our outstanding coordinator Lori Hand from Hamilton who has bravely delved into new territory to enrol our first few DCD patients (3 in total!) and stayed up until all hours of the night to make sure we captured the waveform data. Thank you Lori for being so dedicated!
We are also excited to have St. Michael’s Hospital and London Health Sciences Centre open as active sites this month, and the Queen Elizabeth II Hospital in Halifax begin to ramp up the startup process.
For more information about the latest DePPaRT study updates, please visit our updates page.
The DDePICt research team has been collaborating this month with the DAL lab at the Ottawa Hospital Research Institute and our site lead and biomed teams at SickKids hospital to put together an application for a 2015-2016 Innovation Grant to look at pediatric-specific outcomes. Hopefully more information to come soon if we are accepted for funding!
Congratulations to our team at Calgary Foothills Hospital, who just enrolled their first patient yesterday, and our team at Mount Sinai Hospital in Toronto who also enrolled their first patient this month.
We are so thankful for the support and participation of all our active sites, as well as those sites who are working hard at study startup. As of today, total study enrolment is now at 33 patients, only 8 patients away from the total number enrolled in the DDePICt pilot study!
The DDePICt research team has been hard at work this summer and has recently submitted a grant proposal for funding to look at waveform variability analysis in a subset of DePPaRT patients. The team at the London Health Sciences Centre has also developed a protocol to examine the neurologic changes which occur after WLST and plans on submitting an application for local pilot study funding soon.
Check out more updates on DePPaRT study enrolment here.
The DePPaRT study has been making great progress over the summer, with 8 new enrolments over the past two months and 7 sites now up and running. Check out our latest numbers in the new August update.
We have also now updated the study FAQs page with two documents: one for study coordinators and site investigators which covers questions about study procedures, and a more general page with questions and answers about deceased organ donation and donation after a cardiocirculatory determination of death. You can check out the FAQs here.
Amanda van Beinum
Informing the practice of donation after circulatory determination of death in Canada
The Death Prediction and Physiology after Removal of Therapy study aims to provide information about the physiology of death after withdrawal of life sustaining therapy in the ICU...