This week, Sonny is the focus of CHEO's Spotlight on Research. Click on the video below to watch him explain how our work uncovering the barriers to organ donation is impacting the lives of pediatric donors and their families.
We are pleased to announce that the DePPaRT study has, as of this week, enrolled the 50th patient! Our total count is now at 51 patients - that's 51 deaths in ICU where families made the generous decision to allow us to use the patient's data to improve our knowledge of the physiology of dying, and help to influence organ donation policy.
Thank you to all our consenting families, hard working and cooperative bedside staff, and of course our site study teams who are making this study happen through consistent screening, consenting, and data collection!!
The DePPaRT study has come a long way in the past few months. At 48 patients total, we have now surpassed the number enrolled in the DDePICt pilot study and are only 2 patients away from our next major milestone.
A big thanks to our stellar team in Prague who have now enrolled almost half of all our patients (21 in total, as of today), and our outstanding coordinator Lori Hand from Hamilton who has bravely delved into new territory to enrol our first few DCD patients (3 in total!) and stayed up until all hours of the night to make sure we captured the waveform data. Thank you Lori for being so dedicated!
We are also excited to have St. Michael’s Hospital and London Health Sciences Centre open as active sites this month, and the Queen Elizabeth II Hospital in Halifax begin to ramp up the startup process.
For more information about the latest DePPaRT study updates, please visit our updates page.
The DDePICt research team has been collaborating this month with the DAL lab at the Ottawa Hospital Research Institute and our site lead and biomed teams at SickKids hospital to put together an application for a 2015-2016 Innovation Grant to look at pediatric-specific outcomes. Hopefully more information to come soon if we are accepted for funding!
Congratulations to our team at Calgary Foothills Hospital, who just enrolled their first patient yesterday, and our team at Mount Sinai Hospital in Toronto who also enrolled their first patient this month.
We are so thankful for the support and participation of all our active sites, as well as those sites who are working hard at study startup. As of today, total study enrolment is now at 33 patients, only 8 patients away from the total number enrolled in the DDePICt pilot study!
The DDePICt research team has been hard at work this summer and has recently submitted a grant proposal for funding to look at waveform variability analysis in a subset of DePPaRT patients. The team at the London Health Sciences Centre has also developed a protocol to examine the neurologic changes which occur after WLST and plans on submitting an application for local pilot study funding soon.
Check out more updates on DePPaRT study enrolment here.
The DePPaRT study has been making great progress over the summer, with 8 new enrolments over the past two months and 7 sites now up and running. Check out our latest numbers in the new August update.
We have also now updated the study FAQs page with two documents: one for study coordinators and site investigators which covers questions about study procedures, and a more general page with questions and answers about deceased organ donation and donation after a cardiocirculatory determination of death. You can check out the FAQs here.
Last week, members of the DePPaRT core team (Sonny and I) travelled to Toronto to meet with research coordinators, site investigators, and ICU staff at St. Michael's Hospital and Mount Sinai Hospital. We were warmly welcomed at both sites and enjoyed the opportunity to speak with ICU staff about the DePPaRT study. Site training sessions allow us to help provide bedside staff with the background information they need to feel comfortable and confident with study procedures. They also often challenge us with new perspectives and new questions about donation and end of life care - these presentations are a two way street! From the 7 presentations we did over 2 days we got the sense that staff at both sites understood the DePPaRT study and agreed that more information about the natural process of dying will help to improve care for patients and families, especially for those patients who go on to donate organs.
Thank you to the coordinators, site investigators, and ICU staff at St. Michael's Hospital and Mount Sinai Hospital for your support!
In other news, the Ottawa Hospital General Campus enrolled another patient on Friday, raising the total number of patients enrolled in the study to 14. A big thanks to the patient's family for supporting our study, and to the Ottawa Hospital coordinators for making this enrolment happen!
You can now download monthly study progress updates from our updates page.
After a busy few weeks we are pleased to report continued progress with enrolment and study site startup for the DePPaRT study. We now have 5 sites open and enrolling (Ottawa General and Civic campuses, Montreal General Hospital, CHEO, and Charles University in Prague), and have enrolled 8 patients in June. The total number of patients enrolled to date in the DePPaRT study is now 13!
We are looking forward to starting up the study very shortly at our sites in Toronto, Hamilton, London (Ontario), and Vancouver.
In other news, the DDePICt study team recently published a new article in Critical Care Medicine. "Variations in the Operational Process of Withdrawal of Life-Sustaining Therapy" is a review of practices of withdrawal of life sustaining therapies in North America, Europe, and Australia inspired by the variations in practice observed in the pilot study. Click here to read the abstract on PubMed.
Part of the DePPaRT study involves the collection and electronic download of continuous waveform data from patients who undergo withdrawal of life sustaining therapy in the intensive care unit. This is a lot of data, and collecting, cleaning, viewing, and analyzing it will take some hard work and dedication. For the pilot study we collected waveform data by printing it out from hospital monitors. For the DePPaRT study, we’re collaborating with the Dynamical Analysis Laboratory (DAL) to go paperless. Want to know how? Click here to read more about the DePPaRT waveform viewer.
Sonny Dhanani, the multi-site principal investigator for the DePPaRT study, presented to the group at the annual Canadian National Transplant Research Program (CNTRP) meeting this week at Château Montebello in Montebello, Quebec. For the first time ever, the meeting was held in conjunction with the Spring meeting of the Canadian Critical Care Trials Group (CCCTG). The audience of critical care physicians, organ donation and transplant researchers, transplant patients, and health and policy researchers was very receptive and had some great input towards our proposals of including a special neurological monitoring sub-study. The DePPaRT study team had a great time at the meeting - I had the chance to meet with investigators and coordinators from across the country who will be invaluable in helping us get the study done. We also got to see an emotional and memorable talk by double lung transplant patient Hélène Campbell, who reminded us all of the reasons we continue to work towards the improvement of organ donation and access to donation in Canada.
We'd like to thank the organizers and the chairs of the CNTRP and the CCCTG for putting together a great Spring meeting!
In other news: last Friday our superstar coordinators at the Ottawa Hospital General site enrolled their third patient, making them the highest enrollers so far and bringing the total number of patients enrolled to 6. We also have news that the site at the Montreal General Hospital and St. Michael's Hospital in Toronto have now finalized contracts negotiations and should be starting up soon.
The DePPaRT study enrolled its first international patient this week in Prague, Czech Republic, bringing the total number of patients enrolled in this study to 5!
Congratulations to our collaborators at the Fakulní Nemocnice Kralovské Vinohrady (Charles University) in Prague, Czech Republic, and thank you for your dedication to getting the study up and running. We are optimistic about starting up at several other sites in the Czech Republic in the near future.
The DePPaRT Study may also soon be expanding into the UK. Collaborators Dale Gardiner, Dan Harvey, and their dedicated team of investigators submitted a research grant proposal to the National Institute for Health Research to fund patient enrolment and data collection at 6 major intensive care units across Britain. The UK DePPaRT study will focus on developing a tool to help physicians better predict how long it will take someone to die after the withdrawal of life sustaining therapy and therefore which patients are the best candidates for donation after the circulatory determination of death.
Back in Canada, the Ottawa Hospital Civic campus is now live for enrolment, bringing the total number of active sites to 3 (2 adult, 1 paediatric).
Amanda van Beinum
Informing the practice of donation after circulatory determination of death in Canada
The Death Prediction and Physiology after Removal of Therapy study aims to provide information about the physiology of death after withdrawal of life sustaining therapy in the ICU...